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Bioprinted Human Tissue Models are multi-cellular, dynamic, and functional 3D human tissue models for preclinical testing and drug discovery research. Created using proprietary 3D bioprinting process, the tissues remain viable and dynamic for an extended time in vitro and exhibit key architectural and functional features that mimic key aspects of the natural 3D tissue environment. Biochemical, genomic, proteomic and unique histologic endpoints can be assessed over time.
Bioprinting is an emerging technology to fabricate artificial tissues and organs through additive manufacturing of living cells in a tissues-specific pattern by stacking them layer by layer. Two major approaches have been proposed in the literature: bioprinting cells in a scaffold matrix to support cell proliferation and growth, and bioprinting cells without using a scaffold structure. Despite great progress, particularly in scaffold-based approaches along with recent significant attempts, printing large-scale tissues and organs is still elusive.
Bioprinting is a promising technology in regenerating tissues and organs and has recently gained enormous attention due to its unique benefits, including precise placement of biologics (i.e., cells, growth factors, and genes) to recapitulate heterocellular tissue biology, rapid fabrication of scalable tissue constructs, precise fabrication of anatomically accurate tissue replacement parts, and generation of high throughput assays for pharmaceutical applications such as drug toxicity, drug discovery, and clinical diagnostics
- Functional, 3D human tissues for preclinical testing and drug discovery research
- Complex, multi-cellular 3D human tissues that mimic native tissue biology
- Obtain human tissue data to support better predictive outcomes
- Assess biochemical, genomic, proteomic, and unique histologic endpoints
- De-risk total development costs by capturing failures earlier
Long-term goal of producing human organs-on-demand as well as scaffolds for teeth and related opportunities are on the brink of medical advance today and are seeing positive results and in some cases testimonials of success. Hydrogels are the preferred major class of bioink materials used in tissue engineering. They can be derived naturally or synthetically, and they are widely used to encapsulate cells during the bioprinting process while they mimic the ECM environment, allow cells to grow, possess a degree of flexibility very similar to natural tissue due to their water absorbent characteristics, and are abundant and affordable.
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Stem Cells on Bioprinting Scaffolds
When cells are cultured on them, they allow the cells to quickly proliferate. Cultured cells in microcarriers can then be printed in a delivery medium such as hydrogel. It was demonstrated in a recent study that cells can interact and aggregate better inside the microcarriers than can cells loaded in the hydrogel solution alone