Regenerative Medicine is the future of healthcare, but what product, service or even doctor is right for your condition?

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Regenerative medicine is a new, exciting approach to treating degenerative diseases and injuries that utilizes specially-grown tissues and cells (mostly various stem cells), synthesized compounds, and artificial organs. Targeted and combined applications of these approaches amplify the natural healing ability of the human body in the places it’s needed most and is even capable of replacing the function of a permanently damaged organ or tissue.

The goals of regenerative therapies are to reduce, relieve, and manage specific painful, chronic diseases and dysfunctional conditions, with the purpose of improving function and increasing the patient’s overall quality of life through minimally invasive regenerative procedures. Regenerative medicine shifts the paradigm of treatment to a focus on healing, rather than a focus on pain and disease. By utilizing biomedical stem cell building blocks and growth factors, science can bolster and accelerate the body’s natural healing processes. Regenerative Medicine shifts the paradigm of treatment into a focus on healing and growth, rather than on pain and disease.

  • Nourish: Nourish degenerated tissue with cellular building blocks and growth factors that accelerate the body’s natural healing processes.
  • Rebuild: Use products that are intended for homologous clinical use to repair, reconstruct, and replace the recipient’s cells and tissues.
  • Potency: Leverage new technology, proprietary processing protocols protect the therapeutic elements from donor tissues, preserving concentration, viability, and efficacy increasing success rates..

 

 

What’s Right for ME?

We have brought together some of the top minds, scientists and doctors in the world to help answer some of these questions regarding Exosomes, Wharton’s Jelly, A2M, PRP, Stem cells and more. Here is a collection of responses speaking to Alpha 2 Macroglobulin (A2M), Exosomes, Wharton’s Jelly, PRP and stem cell.

Alpha 2 Macroglobulin (A2M)

Dr. Wallace Brucker, MD : board certified Orthopedic surgeon with offices in Breckenridge Colorado Stem Cell Doctor and Central Wisconsin Stem Cell Doctor. Dr. Brucker is board certified in Integrative Medicine and has received additional, specialized training in the field of stem cell administration, specifically for orthopedic (joint arthritis) conditions.

Dr. Brucker’s initial response: If non-spine related arthritic pain is your problem take time to review potential therapy options, such as alpha 2 macroglobulin (A2M),  that I have had and continue to have great, longer term success.

Typical Conditions Treated by Dr. Brucker:

  • Orthopedic stem cells
  • osteoarthritis of knee
  • osteoarthritis of hip
  • osteoarthritis
  • alternatives to joint replacement
  • knee arthritis
  • hip arthritis
  • non surgical alternatives to knee arthritis
  • non surgical alternatives to hip arthritis

Many conditions are showing great response to stem cell intervention and it is an exciting time for providers and patients who may find benefit from this therapy. We confine our practice to those disease states that are orthopedic in nature but the iSTEMCELL network has many providers in various fields that may be able to help find a A2M Doctor in your area. Thank you for your interest!

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What you should know about A2M:

Alpha 2 Macroglobulin (A2M) is a naturally occurring protein that is found in joints and in a person’s blood.   When a patient has osteoarthritis (the “wear and tear” form of arthritis) or arthritis as a result of joint trauma, the levels of A2M are elevated in the joint.  It has been shown that A2M has a protective effect on articular cartilage.  When cartilage is damaged, the body releases various types of enzymes into the joint to “dissolve” or breakdown the microscopic fragments of cartilage the occur when cartilage is damaged.  In some patients, this release of enzymes starts a vicious cycle:  cartilage is damaged signaling the release of enzymes which damage more cartilage which release more fragments and so on and so on.  A2M stops this process cold.  A2M is a protein molecule that binds to the enzymes thereby inactivating the destructive enzymes.   Unfortunately, in some people the amount of A2M in the joint is not enough to break the vicious cycle.  Here is where my process comes in.  The Doctor will pull fluid out of a knee, for example, and send it off to the lab for testing.  The cost of the test to the patient is typically free or minimal.  This test tells the A2M Doctor how many fragments the patient has per unit volume.  This test is call a FACT test or fibronectin aggrecan complex test.  If the test is positive, this patient would benefit from more A2M being placed into the joint in question.   The provider would extra A2M from a persons blood typically from the arm, spin it down and separate the A2M from the rest of the blood.  Once concentrated, re-inject this A2M into the joint.   The whole proces takes about an hour and costs about $2000-$3000 per /joint (depending on doctor & location).  So far, the beneficial effects have lasted up to 6 months or more.  This is considered a non-surgical alternative to joint replacement for pain relief.  This intervention is not billable to insurance and is charged as a “FEE FOR SERVICE”

Wharton’s Jelly

Whartons Jelly is tissue based flowable allograft derived from Wharton’s Jelly of the umbilical cord. Wharton’s Jelly has been used as an alternative to NSAIDs and steroid injections and helps assist with pain in the field of musculoskeletal injuries. Wharton’s Jelly products contain mesenchymal stem cellular tissue, growth factors and other essential components necessary for regeneration. It consists of high amounts of extracellular matrix components, which are mainly collagen, hyaluronic acid and proteoglycans. In addition, it is an amazing reservoir of many peptide growth factors that are essential to healing and growth. Different than Umbilical Cord Blood, the whartons jelly is from the Umbilical Cord however by God’s design it was more for cushioning of the cord which may lead to the reason many doctors choose it when a condition calls from more cushining like in a knee. The efficiency with which MSCs form colonies is an important factor in determining the overall quality of cells. This essentially means that some cells are “more potent” than others and have higher cell function — or they have a higher capacity to multiply and produce new, healthy cells. Because of this, there have been multiple tests devised to measure both the viability and potency of cells in a specified unit. The most commonly used test that measures the ability of the cells to grow and form colonies in a cell culture is called the colony-forming unit (CFU) assay. The most significant advantage to the CFU assay is that it is able to measure cell function in addition to the number of viable cells. And in fact, most studies show that the number of CFUs in a cell progenitor unit is the single best indicator of viability and potency.

Find a Wharton’s Jelly Doctor >> Wharton’s Jelly Consultation

Umbilical Cord Blood

is an umbilical cord blood (UCB) derived cellular flowable allograft used to regenerate new, healthier cells. Umbilical Cord Blood product is minimally manipulated and cryopreserved to maintain viable and biologically active properties.

Exosomes

These mirco cells (aka. miRNA’s or micro rna’s) are thought to be the signaling cells. At a recent industry convention top doctors from around the world stated that they stand alone or in conjunction with other regenerative medicine products have the potential to change lives, and reduce the overall medicare spend every year by over 1 trillion dollars. This is a huge reach, but their point was that if used at the right time it could save people from very expensive surgeries and treatmenets down the road. Imagine if the joint replacement indusrty did 50% less joints that itself is billions…..

An example would be :

Exosome-mediated fibroblast proliferation

After the cell monolayer was ‘wounded’ using a cell scraper, the cultures were washed and fed with DMEM + 10% exosome-free FBS (Control), or DMEM + 10% exosome-free FBS supplemented with 25µg of pre-adipocyte exosomes (Exosome Treated). After a 5 day incubation, fibroblast proliferation closed the gap between the two edges of the wounded monolayer only in the medium supplemented with exosomes. These data support the notion that factors including exosomes secreted by pre-adipocytes (adipose tissue-derived MSC) play a role in wound healing and tissue regeneration, by facilitating cellular proliferation signaling cells to do the work they were designed to do.

 

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