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Canadian biotech firm SemBioSys has begun UK-based phase I/II trials of its insulin which it produces from genetically-engineered safflower plants. <br /> <br /> It represents the first time that the plant-produced insulin has been used on humans with up to 30 healthy volunteers taking part. The trial will compare the efficacy of SemBioSys’ insulin with two commercially-available forms of insulin. SemBioSys says its version is physically, structurally and functionally indistinguishable from ordinary pharmaceutical-grade insulin. <br /> <br /> "This sophisticated trial is designed to show bioequivalence with respect to insulin concentrations as well as insulin action on blood glucose,” says SemBioSys acting chief medical officer Bruce Given.<br /> <br /> The results of the trial are expected in the first half of 2009. <br /> <br /> SemBioSys announced on 24 December 2008 that Mannkind Corporation has bought an option to licence rights for the plant-produced insulin for $2.5m. The deal was expected to close on 5 January 2009. The option period will end on 31 March 2009.<br /> <br /> Copyright 2009 Institution of Chemical Engineers<br />
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