As we grow older, a number of physiological and biochemical changes occur in our bodies. The skin loses its natural maintenance and repair systems gradually, and the stores of fat under the skin start to diminish, leading to the skin appearing saggy and weak. Dermatologists all agree that a glowing and youthful looking skin can be achieved by nourishing the epidermis with a sound diet, proper hydration and the application of topical skin products determined to be safe and effective. One of the most effective peptides for wrinkle control and collagen production is Argireline. You may want to choose a high integrity financial group to help you manage your money so that you can afford to keep your face young and supple throughout your lifetime.

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Argireline, also known as Acetyl hexapeptide-3 or acetyl hexapeptide-8, is a synthetic peptide anti-aging peptide produced by Lipotec LTD. Company. In cosmetic products, it is a biological active formulation ingredient, present most often in form of a powder or 0.05% Argireline solution. Argireline belongs to neurotransmitters inhibiting cosmeceutical peptide category. It has been derived from the N-terminal end of SNAP-25 protein by following the amino acid sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2.

This hexapeptide mimics the N-terminal end of SNAP-25 and competes with this natural protein for a position in the SNARE complex. As a result, neurotransmitters are not released efficiently and facial contractions are weakened and muscles relaxed, thus inhibiting the formation of wrinkles.

Lipotec, the manufacturing company, claims that the peptide solution has demonstrated a decreased appearance of wrinkle-volume by 20.6% and a reduction of wrinkle-length by 15.9% on average. In support of Lipotec’s assertions, a 2002 study concluded that when Argireline is applied to the epidermis in concentrations higher than 5% it effectively reduces lines and wrinkles by up to 30% after 28 days.

Argireline works in the same manner as the botulinum neurotoxins (Botox, Allergan, Irvine, CA) causing muscle paralysis by inhibiting activity in the presynaptic neuronal exocytosis machinery. Active peptide inhibits skin muscle contraction, especially in the forehead, neck, nasal flare and around the eyes. By inhibiting the contraction of facial muscles, allegedly improves skin texture and tone. It prevents new wrinkles from forming and smooths out old ones. Argireline is also cost effective when compared to invasive, painful surgical procedure or other forms of cosmetic procedures.

Despite the shared similarities between botox and argireline, there are also marked differences between the two

  • Botox is more expensive than Argireline.
  • Botox must be administered every 4-6 months, while Argireline can be used consistently. So, an Argireline treatment lasts.
  • Botox is injected into the skin, while Argireline is applied topically.
  • Unlike Botox, Argireline is a non-toxic product. Botox may cause difficulty speaking, swallowing or breathing. Problem with vision is also common.
  • Due to the application process, Botox is able to penetrate deeper into the skin. Therefore, it may last longer or appear more effective at smoothing skin.
  • When performed by an experienced doctor, it is relatively safe. But with one incorrect injection, Botox could compromise facial movements and give a patient an unnatural expression.

Will long-term use of Argireline lead to Skin Sagging?

There are fears and concerns, that long-term use of Argireline will cause skin sagging. There is subjective evidence that suggests the prolonged use of Argireline may cause skin sagging and dropping in some individuals. Some users have complained about issues relating to brain fog following long-term use. However, there is no scientific data to support or disprove either of these claims.

A 2013 Chinese randomized, placebo-controlled Argireline study, one of the only studies featuring human patients (60 subjects) – also notes contradictions and concludes that despite being safe and somewhat effective, the ability of Argireline to permeate skin is inadequate, resulting in significant waste. The study concluded that Argireline may be more beneficial to older people with thin skin. This is because the younger individuals have thicker skins which may be too substantial a barrier for Argireline to reach pivotal connections of nerves and muscles.

While not everyone reports any side effects with Argireline, if you have a sensitive skin, you may experience burning and stinging sensations upon application as well as redness and dry, flaky skin at contact points. The manufacturers also caution against applying products that contain a peptide to the sunburned or irritated skin.

What is the Best Ingredient for Aging Cream?

With as many different skin care products on the market as there are, it can be a challenge choosing the right anti-aging ingredients suitable for your skin type. Some of the most popular ingredients in skin care products to help prevent skin aging include;

  • Retinol: Retinol is a very potent antioxidant that fights against oxidative free radicals and reduces signs of aging. It is an active form of vitamin A.
  • Hyaluronic acid: This is one of the main ingredients in keeping your skin soft and hydrated. It is a powerful moisturizer.
  • Jojoba oil: Jojoba oil is rich in zinc, vitamin E, and B-complex vitamins. When used regularly, it can help control acne and lighten dark circle rings underneath the eyes.
  • Glycolic acid: It is known for its ability to enhance collagen and elastin production in the body, thereby reducing the signs of aging in the body.

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Blanes-Mira, C., Clemente, J., Jodas, G., Gil, A., Fernandez-Ballester, G., & Ponsati, B. et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal Of Cosmetic Science24(5), 303-310. doi: 10.1046/j.1467-2494.2002.00153.x

Blondelle, S., Houghten, R., & Pérez-Payá, E. (1996). AllD-amino acid hexapeptide inhibitors of melittin’s cytolytic activity derived from synthetic combinatorial libraries. Journal Of Molecular Recognition9(2), 163-168. doi: 10.1002/(sici)1099-1352(199603)9:2<163::aid-jmr255>;2-6

Dahiya, R. (2008). Synthesis and biological activity of a cyclic hexapeptide from Dianthus superbus. Chemical Papers62(5). doi: 10.2478/s11696-008-0052-9

Wang, Y., Wang, M., Xiao, S., Pan, P., Li, P., & Huo, J. (2013). The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects. American Journal Of Clinical Dermatology14(2), 147-153. doi: 10.1007/s40257-013-0009-9