Doctors near me doing stem cell injectionsHodgkin lymphoma is an uncommon cancer that develops in the lymphatic system, which is a network of vessels and glands spread throughout your body. There are two types of lymphoma, they include Hodgkin’s and non-Hodgkin’s lymphoma. Hodgkin’s lymphoma is more common than the non-Hodgkin’s lymphoma. This blood disorder can affect people of any age group, however, it’s more prevalent among people between the ages of 20 and 40 years old. In Hodgkin’s lymphoma, the cells in the lymphatic system develop abnormally, and might also move from where they are to other parts of the body. Some of the symptoms of this disorder include fever, loss of weighing and night sweats. Also, the patient would experience an enlargement of the lymph nodes, especially in the neck, axilla, and the groin. The most common and prevalent cause of Hodgkin’s lymphoma is Epstein-Barr virus, however, there are some other risk factors that could also cause the disease. Some of them are HIV/AIDS. This medical condition can be diagnosed by identifying the special and abnormal cell, called the Reed- Sternberg cells in lymph nodes. Hodgkin’s lymphoma is not an easy condition to manage. However, there are some treatment procedures that are usually performed. They include radiotherapy, chemotherapy, and stem cell transplant. Stem cells are harvested from the patient, frozen, then transplanted back after some procedures. Physicians also buy stem cells online. The type of procedure that’ll do depends largely on the severity of the disease, and how advanced the disease is. It’s possible for this disease to be cured, especially when it’s diagnosed early. The earlier the disease is diagnosed, the better the prognosis. Physicians can buy stem cells online for the management of this medical condition

What Causes Hodgkin’s Lymphoma?

The exact cause of Hodgkin’s lymphoma isn’t known yet, however, Hodgkin lymphoma is said to be caused by a change (mutation) in the DNA of a type of white blood cell called B lymphocytes. The development of this disease starts when a lymphocyte undergoes a genetic mutation to form an abnormal cell. This causes the cell to proliferate rapidly, more than the normal and healthy cells. The rapid rate of proliferation of the Hodgkin lymphoma cells is the reason why the disease spreads so fast and is so life-threatening, especially when it’s not well managed. These abnormal lymphocytes multiply rapidly and deposit themselves in the lymphatic system. Eventually, they tend to overcrowd and replace the healthy and normal lymphocytes in the lymphatic system. There are different types of Hodgkin’s lymphoma. The type of Hodgkin’s lymphoma that is diagnosed will determine the kind of treatment the patient would get.

Types of Hodgkin’s Lymphoma

The World Health Organisation’s (WHO) classification system puts Hodgkin lymphoma into 2 main classes. They are:

  • Classical type –This is the most common form of Hodgkin lymphoma and it is characterized by the presence of Reed Sternberg cells.
  • Nodular lymphocyte predominant type – This is less common than the Classical type. It’s more common in older people but can occur in young people. The main difference between this type and classical Hodgkin lymphoma is that in the nodular lymphocyte predominant type there are very few Reed-Sternberg cells. But there are other abnormal cells that doctors call popcorn cells.

 

What Are The Signs And Symptoms Of Hodgkin’s Lymphoma?

People affected by Hodgkin’s lymphoma usually presents with a lot of signs and symptoms. Below are some of them;

  1. Lymph nodes: One of the most common symptoms of Hodgkin’s lymphoma is the painless swelling of the lymph node (sometimes it might ache). This might affect just one lymph nodes, and can as well affect more than one. The nodes usually have a rubbery texture, and swollen when touched, The nodes that are most affected are the lymph nodes of the neck, armpit, groin, and shoulder. The chest lymph nodes are also affected. All these can be detected by doing an imaging test, such as the chest x-ray.
  2. Night sweats: People affected by this disorder usually experience night sweats. This shares a similarity with one of the symptoms of tuberculosis. However, tuberculosis is usually accompanied with bloody sputum. Tests should be done to differentiate the two diseases. This is one of the early symptoms of Hodgkin’s lymphoma
  3. Loss of weight
  4. Enlargement of the spleen: This occurs in up to thirty percent of all Hodgkin’s lymphoma cases. However, the size of the spleen increases mildly and moderately. It’s rare for the spleen to become overly enlarged. The size of the liver may also alternate during the course of treatment.
  5. Liver enlargement: Although this isn’t a common symptom, it still occurs in about five percent of cases.
  6. Pain in the lower back: Patients often experience pain in the lower part of their back. This pain cannot be pinpointed to a particular part of the lower back.
  7. Pain associated with alcohol consumption: Lymph nodes usually becomes painful, especially after the consumption of alcohol. This occurs in a small fraction of those affected by the disease. The pain starts some minutes after alcohol has been consumed. Patients have described the pain as sharp, dull and stabbing.
  8. Other symptoms due to abnormal cells in the bone marrow include Breathlessness, fatigue, excessive bleeding and an increased risk of infection.
  9. Nephrotic syndrome: This disease is predominant in patients affected by Hodgkin’s lymphoma. It is mostly as a result of the minimal change disease.

What Are The Risk Factors For Hodgkin’s Lymphoma?

There are some factors that increase the risk of having Hodgkin’s lymphoma. They include the following;

  1. Ebstein Barr Virus/Infectious Mononucleosis: People who have had infectious mononucleosis have an increased risk of developing Hodgkin’s Lymphoma.
  2. Family history: People that have a relative that was affected by Hodgkin’s lymphoma have a high chance of also developing the disease. This kind of people should go for regular checkups, especially when they notice any changes in their health.
  3. Gender: Gender also plays an important role. Generally, males are more predisposed to having Hodgkin’s lymphoma as compared to females.
  4. Age: Hodgkin’s lymphoma can affect all age groups. However, it’s most common in early adulthood (especially in a person’s 20s) and in late adulthood (after age 55).
  5. Weakened Immune System: The risk of Hodgkin’s Lymphoma is increased in people infected with HIV, the virus that causes AIDS. People who take medicines to suppress the immune system after an organ transplant and people with auto-immune diseases are also at higher than normal risk for Hodgkin’s Lymphoma.

 

Treatment of Hodgkin’s Lymphoma?

Hodgkin’s lymphoma can be cured. However, this depends on the type of Hodgkin’s lymphoma, and the staging of the disease. Usually, the earlier the disease is diagnosed, the better the prognosis. Some of the procedures used include chemotherapy, radiation therapy, immunotherapy and bone marrow transplant.  Except for biopsy and staging, surgery is rarely used to treat Hodgkin’s Lymphoma.

How Stem Cell Therapy can be used to treat Hodgkin’s Lymphoma

A bone marrow transplant is one of the most effective methods used in treating this disease.  Stem cells are harvested from the patient, frozen and kept till it’s needed. The next stage is to eliminate the abnormal and cancerous cells of the patient through chemotherapy and radiotherapy. The new stem cells are then transplanted to the patient, to form entirely new cells.

References

Akhtar, S. (2017). High dose chemotherapy and autologous stem cell transplantation in relapsed or refractory Hodgkin lymphoma: Emerging questions, newer agents, and changing paradigm. Haematology/Oncology and Stem Cell Therapy, 10(4), pp.272-276.

Crump, M. (2008). Management of Hodgkin Lymphoma in Relapse after Autologous Stem Cell Transplant. Haematology, 2008(1), pp.326-333.

Kahl, B. (2007). Dose-Intense and Dose-Dense Regimens in Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphoma. Clinical Lymphoma and Myeloma, 8, p.S42.

Kako, S., Izutsu, K., Kato, K., Kim, S., Mori, T., Fukuda, T., Kobayashi, N., Taji, H., Hashimoto, H., Kondo, T., Sakamaki, H., Morishima, Y., Kato, K., Suzuki, R. and Suzumiya, J. (2014). The role of hematopoietic stem cell transplantation for relapsed and refractory Hodgkin lymphoma. American Journal of Hematology, 90(2), pp.132-138.